CC at: rs12203592 - No pigmented Collarette.TT at: rs1667394 - Starburst (Collarette).As a doctor, the last thing I say to my patients is, Are there any more questions you. GG at: rs16891982 - Starburst (Collarette) Blue light is just above the UV light with high energy wavelength.GG at: rs12906280 - Gray ring around outer edge.TT at: rs1129038 - Penetrance modifier.CT at: rs989869 - Contrasting sphincter around pupil.What causes green eyes Genetics play a role in determining eye color. In Iceland, a survey of the population revealed 89 of women and 87 of men have blue or green eye color. CC at: rs9782955 - Blocks some melanin. For example, in Edinburgh, Scotland, it's estimated that 29 of residents have green eyes (57 have blue eyes and only 14 have brown eyes).Basis for Gray, Blue, Green, or Yellow Eyes if no other pigmentation is present. GG at: rs7174027 - Blocks some melanin.This is called the Tyndall Effect, which is the way that light scatters in blue eyes, giving rise to the blue appearance. CC at: rs3794604 - Blocks some melanin. According to the American Academy of Ophthalmology, blue eyes look blue for the same reason that both the ocean and the sky appear to be blue: its simply a trick of the light.In some cases, a rule cancels out results from rules above it. More recently, one potentially functional OCA2 SNP that is part of a 13 SNP haplotype covering 166kB located at the other side of the gene has been found in 97% of individuals with blue eye color :Įye color of someone with albinism eye picture The following OCA2 variants, all located in the first intron of the gene, have been linked to blue eye inheritance together, they form a haplotype that occurs in 90% of individuals seen with blue or green eye color, but can also be seen in 10% of individuals with brown eye color. One gene with a significant role in determining blue eye color is OCA2, a gene with variants first linked to albinism and perhaps melanoma risk. rs1667394(A) - in thearticle, this one was the only HERC2 given in plus orientation.This 2012 article identifies 3 distinct haplotypes for blue eye color.īEH1 : blue-eye associated haplotype #1 gs255 gs256 OCA2īEH2 blue-eye associated haplotype #2 gs257 gs258 HERC2 minus orientationīEH3 blue-eye associated haplotype #3 gs259 gs260 HERC2 In a population sense, it should be noted that all populations except Caucasians basically have brown eyes, while amongst Caucasians one categorization that researchers track is blue vs non-blue. The genetics of eye color, like hair color, are still being worked out, and it's clear that several genes can modify the eventual outcome.
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